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Gotu Kola is present the composition of V-3, and it contains several active compounds, principally triterpenoid saponins. Studies report that is strengthens the structure of the connect tissue and reduces the quantity of serum enzymes in the varicose veins. it is reported thatthe compound Aescin (or Escin) present in Horse Chestnut suppresses the enzymes disintegrating support structures of the veins,thereby increasing flexibility of the veins and supports the regulation of the blood circulation. Grape Seeds help to prevent skin damage.