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The free radicals occur naturally as the result of metabolism in the body or are taken externally via smoking, ultraviolet rays,radiation, herbicide,pesticide and air pollution.Those components cause the destruction of structures by effecting ali important components of the cells such as lipid, protein, ONA and carbohydrate and consequently, death of cells. Antioxidants helps to prevent the chain reactions that may cause the coronary diseases and early aging by making the free radicals neutralized.

During the executed studies, it is stated that the molecules, which exist in the grape seeds anda re standardized as the oligomeric proantocyanides -OPS's- are more efficient than the strong antioxidants such as vitamins C,E and beta-carotene.