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The sharks are the living creatures which have the lower possibility of catching diseases with their strong immunity systems and have longer life- cycles. in this strong immunity system, it was thought that the protein in the sharks cartilages and some substances in the mucopolysaccharide structure played the role and the researches have focused on this issue.

Glucosamine and chondroitin sulfate in the Shark Cartilage are the important agents to protect the joint health. Glucosaminoglycants (GAG ), which are the active agents of chondroitin sulfate, are the important components of the ligament tissue.